3. GSM Treatments
Therapies with local Vaginal (GSM) Benefit
Therapies with local Vaginal Benefit | Doses |
Vaginal Estrogens | |
Vaginal Cream: Conjugated Equine Estrogen (PremarinⓇ) | 0.5 – 1.0 gm nightly pv x 2 weeks then 2/week* differs from product monograph |
Vaginal Cream: Estrone (Estragyn®) | 0.5 – 1.0 gm nightly pv x 2 weeks then 2/week* differs from product monograph |
Vaginal Tablet: 17B Estradiol (VagifemⓇ) | One tablet pv nightly x 2 weeks then 2/week |
Vaginal softgel insert: 17B Estradiol (ImvexxyⓇ) | 4 mcg or 10 mcg nightly pv x 2 weeks then 2/week |
Vaginal Ring: 17B Estradiol (EstringⓇ) | Change ring q3 months |
Vaginal DHEA | |
Vaginal Insert: Prasterone (IntrarosaⓇ) | 6.5 mg pv daily |
Oral agent for GSM | |
SERM: Ospemifene (OsphenaⓇ) | 60 mg po daily |
There are no studies at this time supporting the use of vaginal prasterone with systemic MHT.
Oral ospemifene cannot be combined with systemic MHT.
For a full listing of hormonal products and non-hormonal medication options click here